শুক্রবার, ২১ জুন, ২০১৩

Idenix sees delay in human trials for hep C drug as FDA seeks more data

(Reuters) - Idenix Pharmaceuticals Inc said it expects a delay in human trials of one of its experimental hepatitis C drugs after the U.S. Food and Drug Administration asked for additional safety data, sending its shares down 21 percent after the bell.

Clinical trials of the drug, codenamed IDX20963, has been put on hold until it provides a satisfactory response to the FDA, Idenix said in a statement.

Hepatitis C is an disease that affects the liver and if left untreated can lead to cirrhosis, cancer or need for a transplant.

In early February, the company stopped the development of two other hepatitis C drugs, IDX184 and IDX19368, after the FDA continued with a clinical hold, initiated following the death of a patient in a mid-stage trial conducted by Bristol-Myers Squibb Co using a similar compound.

"This signifies that the preclinical/clinical development of any nuc is likely even more challenging than anticipated," Oppenheimer & Co analyst David Ferreiro said in a note.

Idenix's hepatitis C drugs have been developed using a technology called polymerase inhibitors, or nucs. Nucs prevent the virus from multiplying and represent a new class of drugs for the disease.

IDX20963 belongs to a sub-class of nucs called uridine nucleotide, and the company has said previously that it is distinct from the two drugs whose development was stopped.

Ferreiro also noted that this setback occurred even when the drug -- a uridine analog is deemed safer than other nucs.

"Consequently, we continue to hold low expectations for IDX20963's ultimate success," he said.

Idenix shares were down at $4.03 in after-market trading. They closed at $5.13 on the Nasdaq on Thursday.

(Reporting by Pallavi Ail in Bangalore; Editing by Sriraj Kalluvila)

Source: http://news.yahoo.com/idenix-sees-delay-hep-c-drug-human-trials-215236297.html

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বৃহস্পতিবার, ২০ জুন, ২০১৩

Obama pushes big cut in nuclear weapons. Is that a good idea?

In Berlin, President Obama calls for cutting US deployed nuclear weapons by one-third and urges NATO allies to pursue 'the security of a world without nuclear weapons.'

By Peter Grier,?Staff writer / June 19, 2013

President Obama waves before speaking at the Brandenburg Gate in Berlin on Wednesday. Mr. Obama called for a reduction in the world's nuclear stockpiles, including a proposed one-third cut in US and Russian arsenals.

Evan Vucci/AP

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In a Berlin speech on Wednesday, President Obama proposed cutting deployed US strategic nuclear weapons by one-third. These reductions would occur pursuant to US-Russian negotiations aimed at getting the world?s two big nuclear powers to move beyond ?cold war nuclear postures," Mr. Obama said.

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The US president also said he would work with NATO allies to see big cuts in smaller, tactical nuclear weapons based in Europe.

?Peace with justice means pursuing the security of a world without nuclear weapons ? no matter how distant that dream may be,? said Obama.

Obama?s new move to slash US and Russian arsenals comes two years after the last arms agreement between the two nations, New START, went into effect. That pact calls for both to reduce their deployed strategic nukes to 1,550 each by 2018. Further one-third cuts would result in a level of approximately 1,000 such weapons.

Given that the US had an estimated 10,000 strategic warheads in 1980, are further cuts to the 1,000 level a good idea?

Many nuclear experts believe that yes, it would be a good thing. The cuts would lighten the load of nuclear arsenals while still providing enough power to keep the US safe, some say.

One thousand strategic weapons ?are still more than sufficient to assure that the US can deter any major adversary from launching major strikes against the US,? said Jon Wolfsthal, Vice President Joe Biden?s former nuclear adviser and current deputy director of the James Martin Center for Nonproliferation Studies,?in a video commentary.

The reduction would allow the US to cut back on plans to build a new generation of nuclear delivery vehicles, saving $58 billion over the next decade, according to an Arms Control Association statement on the speech.

Obama?s push might help NATO and Russia overcome ?inertia? on tactical nuclear weapons, the ACA added. Russia maintains some 2,000 tactical nukes, of which 1,000 are obsolete air defense warheads, according to an ACA estimate. The US maintains 180 air-delivered nuclear bombs in Europe, in part because some US NATO allies see them as insurance against aggression from Moscow.

Nor do these moves depend on signing a formal new agreement, argued ACA. The US and Russia could simply move forward with parallel, reciprocal reductions.

?In the months ahead, President Obama must re-energize and sustain the nuclear risk reduction enterprise and US policymakers must overcome partisan politics to help address today?s grave nuclear challenges,? writes ACA executive director Daryl Kimball.

Some Republicans believe Obama?s proposal could harm US national security if implemented, however.

Rep. Michael Turner (R) of Ohio, a member of the House Armed Services Committee, charged Obama with cozying up to America?s former superpower nuclear adversary. The president ?seems only concerned with winning the approval of nations like Russia, who will applaud a weakened United States,? said Representative Turner, according to the Associated Press.

At the right-leaning Heritage Foundation, defense analyst Michaela Dodge says?Obama?s moves could sow doubt in the minds of allies and adversaries alike as to the solidity of US nuclear guarantees.

The House Armed Services Committee?s version of fiscal year 2014 defense authorization legislation prohibits elimination of the nuclear triad (bombers, submarines, and ballistic missiles) while limiting the availability of further funds for nuclear reductions, points out Ms. Dodge.

?It is only prudent to wait and assess the effects of the reductions under New START before conducting yet another round of unilateral nuclear weapons reductions, because the treaty does not provide for predictability, and its degraded verification regime makes it more difficult to assess Russia?s nuclear weapons capabilities,? she writes.

There?s also the question of whether Russia is interested in further nuclear cuts. This is especially apropos in light of the strained personal relations between Obama and President Vladimir Putin evident at the recent G8 summit in Northern Ireland.

Alexei Pushkov, head of the foreign affairs committee of the Russian Duma, told Interfax that Obama?s proposals need ?serious revision so that they can be seen by the Russian side as serious and not as propaganda proposals," according to AP.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/i-jDlJhn1hE/Obama-pushes-big-cut-in-nuclear-weapons.-Is-that-a-good-idea

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Union bring in Oka Nikolov to push Zac MacMath

CHESTER ? The central theme of Philadelphia Union manager John Hackworth?s roster philosophy is the notion of competition.

Wednesday, the club shored up one of the major areas in which that level was lagging.

The Union came to terms with free-agent goalkeeper Oka Nikolov, who has played for the last 22 years with German side Eintracht Frankfurt. Terms of the deal between the club and the 39-year-old ?keeper were not disclosed, per league policy.

The acquisition is pending receipt of a visa for Nikolov, who holds dual German and Macedonian citizenship and has been capped five times by the latter national team. He?s not available to play for the Union until the MLS summer transfer window formally opens July 9, making the July 12 meeting with Chivas USA the first match he?d be eligible for.

?He is first and foremost a fantastic person,? Hackworth said Wednesday at his weekly press conference. ?Something we believe very strongly in is the character of the people we bring into our club, and he certainly epitomizes that. I met with him and was impressed with him as a person as much as his playing record. The fact that he was at Eintracht Frankfurt for so long and is in high regard there says volumes about him as a person and as a player.?

The nuts and bolts of Nikolov?s role with the Union aren?t fully clear, but certain aspects are. First and foremost, there?s the effect on No. 1 goalkeeper Zac MacMath.

?Zac?s absolutely, 100 percent still the starter,? Hackworth said. ?No question about that.?

A large part of Nikolov?s role is also pre-determined, as he?ll come in to serve as a mentor for MacMath, who will turn 22 later this summer and is in his second year as a full-time starter, and backup Chris Konopka, who at age 28 is still in the long-term plans of the Union, according to Hackworth.

But part of that mentorship will be to push both players on the pitch for playing time. Like anyone else, Hackworth has explained to Nikolov that he will have to prove himself to the team and earn whatever minutes may come his way. But his addition is ultimately as a player, not a coach, and the expectation is that he?ll play some role on the pitch beyond merely sharing his experiences. Continued...

?I wouldn?t bring a guy here just to be a practice player in most situations,? Hackworth said. ?But the reason that Oka is coming here is to prove that he can still play at this level in this league. It?s a challenge that he has set out for himself very clearly, but I also think he understands the role and what this means for our club. If Oka plays so well and he deserves it, he?s going to play. But he?s going to have to do an awful lot in our coaching staff?s opinions to unseat our whole feeling about the potential of Zac MacMath and how good he is and how good he can be given the proper pressure even from within the team to improve and make himself better.?

Nikolov may have a lot of miles on the odometer, but that doesn?t mean his career is done. The veteran showed that in recent months at Frankfurt, the club he?s been at since 1991 ? the year MacMath was born. After 18 seasons and 379 league appearances in the first team ? including leading the club to the final of the domestic cup, the DFB Pokal, in 2006 ? Nikolov presided over a large part of the 2010-11 campaign in which Frankfurt was relegated from the Bundesliga.

He helped them return to Germany?s top flight the following year by finishing second in the 2.Bundesliga but was replaced as the starter in 2012-13 by young goalkeeper Kevin Trapp, a rising star in the German youth ranks.

Nonetheless, the veteran returned to a role on the bench, and when Trapp was injured with eight games left in the season, Nikolov stepped in ably. He went 3-2-3 in Frankfurt?s stretch drive, including results in the last five matches (2-0-3) to cap a Cinderella season that saw the club qualify for the Europa League by finishing sixth in the Bundesliga.

It?s the kind of quality that has Hackworth thinking that Nikolov can bring out the best from MacMath. The Union manager is quick to point out the difference between this instance and the last time the Union signed an aging goalkeeper from a German club ? then-39-year-old Faryd Mondragon from Cologne to be the No. 1 for the 2011 season.

While MacMath is the unquestioned starter at this juncture, that could change. The Union are tied for the third-most goals allowed in MLS with 24 and are the only one of the 10 teams in playoff position to have allowed more than 20. Among regular goalkeepers, MacMath ranks third-last in goals against average (1.60) and fifth-worst in save percentage (66).

Hackworth, though, is confident that by having Nikolov follow the same blueprint as the other veteran arrivals to the youthful core of this team, the pressure on MacMath can be harnessed and kept in check.

?It?s certainly a concern, but I think our coaching staff has a lot to do with the players? confidence and where they feel they stand,? Hackworth said. ?For instance, if Oka?s first chance is July 12 and I fly him in and the next day I start him, yeah if I were Zac, I?d be pretty rattled about it. But that?s not the way we?re going to approach this at all. ? Zac knows the situation. He knows he?s still No. 1. He knows that we still believe in him, we trust in him and he?s got a long and hopefully as illustrious a career as Oka has.?

l l l

The Union?s lone injury concern for Sunday?s visit from New York Red Bulls (5 p.m., ESPN2) is Kleberson, who is working his way back to fitness after a hamstring injury. Hackworth called it a ?slow process? and listed him as questionable for the match. Fellow midfielder Michael Lahoud is back in full training after a sports hernia injury and is likely ready for selection. Continued...

Source: http://delcotimes.com/articles/2013/06/19/sports/doc51c236a095669478634684.txt

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Air Camera for iPhone and iPad lets you stream live camera content to an Apple TV via AirPlay

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Air Camera for iPhone and iPad

Air Camera + Live Streaming for Camera and Voice is an app for iPhone and iPad that lets you stream live?sound and image from iOS devices directly from the camera and microphone input to your Apple TV. This uses AirPlay feature in the iOS to connect to the Apple TV. ?In addition this also lets you add effects to the streaming video and also switch between the front and rear camera.

Features of Air Camera?+ Live Streaming for Camera and Voice for iPhone and iPad

  • Choose between front and back camera
  • Stream pictures in real time to AppleTV
  • Stream sound in real time to AppleTV
  • Use the camera from the iPhone, iPad or iPod as streaming device
  • Stream sound and image from iOS devices without previous recording, directly from the camera and microphone input
  • Choose between front and back camera
  • Air Camera turns your iPhone, iPod or iPad in a live streaming device, reproducing the camera and microphone input in real time via AirPlay.
  • Record and save streams
  • Add effects in real time
  • Refine your stream with Sepia FX, Grey FX, Cartoon FX

Download?Air Camera for iPhone and iPad from the Apple iTunes Store for $0.99 / Rs. 55.

Related Posts with Thumbnails

Source: http://www.fonearena.com/blog/73166/air-camera-for-iphone-and-ipad-lets-you-stream-live-camera-content-to-an-apple-tv-via-airplay.html

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Rounds video chat app now lets friends web browse together during ...

Rounds Video Chat and Calling for iOS and Android updated on Tuesday with a new co-browsing feature that enables friends to conduct live video conversations and?securely browse the web together.

A?partnership with Channel.me has integrated the Dutch start-up's co-browser technology into Rounds' iOS and Android?apps, enabling the?synchronisation of touchscreen activity between two mobile users.?

Rounds requires a Facebook friendship for two users to launch video chats with each other.?In addition, thanks to today's update, friends can now surf the web and control their browsing experience. Specific functionality includes clicking links and typing in new URLs. Friends can also view each other's live video streams via a thumbnail preview that's enabled during co-browsing.

Read:?Google+ Hangouts now available, unified messaging and video calling

Rounds' video chat app is similar to Google Hangouts, which?allows people to communicate with each other across platforms over the internet via video calls, talking, texting, sharing photos and much more. However, unlike Google's offering, Rounds is the self-dubbed "first hangout network to let friends securely surf the web together during live video conversations".

Co-browsing works with Google Search, Wikipedia, Preen.Me, Twitter, Instagram, Pinterest, Reddit, Amazon, eBay, ESPN, The Huffington Post, wanelo, Imgur and TheFancy. It also offers?interactive features such as playing HTML5 games during video chats, watching YouTube videos, adding filter effects, doodle capability over each other's video streams and photo-uploading.

As for security, although the video stream depicts two friends as if they're browsing together on one computer in the same location, Rounds clarified that passwords are not visible during the login process.?

The updated Rounds Video Chat and Calling app is available as a free download on Apple's App Store and Google Play. The company said it expected to add more features throughout summer 2013.

Source: http://www.pocket-lint.com/news/121842-rounds-video-chat-app-now-lets-friends-web-browse-together-during-calls

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মঙ্গলবার, ১১ জুন, ২০১৩

AP PHOTOS: Turkey protesters face riot police

A protester holds a flag depicting jailed Kurdish rebel leader Abdullah Ocalan as a van burns during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013.Hundreds of riot police overran improvised barricades at Istanbul's Taksim Square on Tuesday, firing tear gas, rubber bullets and water cannons in running battles with protesters who have been occupying the area for more than a week. (AP Photo/Vadim Ghirda)

A protester holds a flag depicting jailed Kurdish rebel leader Abdullah Ocalan as a van burns during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013.Hundreds of riot police overran improvised barricades at Istanbul's Taksim Square on Tuesday, firing tear gas, rubber bullets and water cannons in running battles with protesters who have been occupying the area for more than a week. (AP Photo/Vadim Ghirda)

A protester holding a slingshot runs past burning construction vehicles during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013. Some hundreds of police in riot gear forced their way through barricades in the square early Tuesday, pushing many of the protesters who had occupied the square for more than a week into a nearby park. (AP Photo/Vadim Ghirda)

Turkish riot police fire tear gas during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013. Some hundreds of police in riot gear forced their way through barricades in the square early Tuesday, pushing many of the protesters who had occupied the square for more than a week into a nearby park. (AP Photo/Vadim Ghirda)

Turkish riot police fire tear gas during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013. Some hundreds of police in riot gear forced their way through barricades in the square early Tuesday, pushing many of the protesters who had occupied the square for more than a week into a nearby park. (AP Photo/Vadim Ghirda)

Protesters seek cover as riot police charge during clashes at the Taksim Square in Istanbul Tuesday, June 11, 2013. Some hundreds of police in riot gear forced their way through barricades in the square early Tuesday, pushing many of the protesters who had occupied the square for more than a week into a nearby park. (AP Photo/Vadim Ghirda)

Hundreds of police in riot gear attempted to clear Istanbul's central Taksim Square of anti-government protesters who have been occupying the area for more than a week. Police used tear gas and water cannon against the crowd. Protesters exploded fireworks, threw stones and waved banners as several fires burned in the square.

Here are images from the clashes.

Follow AP photographers and photo editors on Twitter: http://apne.ws/15Oo6jo

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-06-11-EU-Turkey-Protest-Photo-Gallery/id-c8381cc137f748259b44a2456f0a14b4

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Sony PlayStation 4 price: $399

Sony PlayStation 4 price $399

Sony has finally revealed release information about its PlayStation 4 console: that it plays used, lent or rented games with no restrictions and its price: $399. That translates to 399 euros, and £349 where applicable, or if you missed it, $100, 100 euros and £70 less than what Microsoft just announced for the Xbox One. There's no specific release date or month yet, just "this holiday season" in the US and Europe. The official spec list confirms that for four bills, you get the system, a controller, USB, HDMI and power cables -- but no PlayStation 4 Eye.

So tell us, has this made your decision any easier? Pre-orders are open now.

Follow our liveblog for all of the latest news from E3 2013.

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Source: http://www.engadget.com/2013/06/10/sony-playstation-4-price/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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